INNOVATE® Philadelphia: 250 Years of Innovation

US WorldMeds is a specialty pharmaceutical company guided by a clear purpose: to improve the lives of patients facing rare and serious conditions. With a focus on areas that are often overlooked, the company is committed to identifying unmet needs and delivering therapies that create real impact for patients, families,...

As the nation celebrates its semiquincentennial, Penn Medicine’s Pennsylvania Hospital marks its own milestone anniversary year with a new museum. This immersive experience highlights the hospital’s unique role in the history of medicine—while still actively making history. For nearly three centuries, Pennsylvania Hospital has been at the forefront of innovation....

Philadelphia is universally recognized as the birthplace of American independence, the city where the Nation’s foundational documents were fiercely debated and boldly signed. Yet, intricately woven into the city’s DNA is another monumental birthright: it is the birthplace of the United States Navy. In the fall of 1775, a Continental...

Century Therapeutics is a Philadelphia-based, biotechnology company working to reimagine the potential of cell therapy across a number of serious diseases. The company is developing investigational cell therapies derived from induced pluripotent stem cells, or iPSCs, to potentially treat autoimmune diseases, like Type 1 diabetes (T1D), as well as cancer....

As Philadelphia marks its 250th year, the city continues to evolve economically, culturally, and physically. In a World Heritage City, the built environment plays a defining role in shaping how institutions perform, how communities connect, and how opportunity expands. FIFTEEN Architecture + Design approaches this responsibility with a clear belief:...

You may not find “Humble Beginnings” or “soul-searing passion” in the nutrition facts of any label – on any product – in all the world; but at 1540 E Wadsworth Avenue in Philadelphia, it’s been a key ingredient. June 26, 2026 will make 30 years of business for David Simms....

Reflecting the evolving spirit of Philadelphia Hopeworks is a nonprofit workforce accelerator that connects young adults ages 17–26 to living-wage careers while helping employers meet growing talent demands. Through paid, self-paced training, real-world work experience, and trauma-informed support, participants move from unemployment to careers with long-term growth and stability. Training...

For more than 40 years, Laboratory Testing (LTI) has inspected the parts that keep aircraft flying, Navy submarines diving, and defense platforms operational. The work is quiet, exacting, and non-negotiable. When an aircraft engine spins up at takeoff, or a submarine eases away from a pier on its first underway...

Philadelphia is home to some of the most respected hospitals and medical institutions in the country. And yet Black mothers in this city are still more likely to experience severe maternal complications, more likely to report feeling unheard, and more likely to navigate postpartum anxiety, depression, and trauma without sustained...

Philadelphia Youth Basketball (PYB) was launched in 2015 with a bold vision: to help young people build positive and powerful lives. PYB has spent the past decade leveraging the iconic game of basketball by building a holistic program, a robust organization, and a world-class Center that provides a comprehensive array...

For more than a century, Rhoads Industries, Inc. has quietly evolved alongside the American industrial landscape. What began in 1896 as a small Philadelphia-based operation has grown into a key contributor to the nation’s maritime and defense infrastructure. The company’s origins trace back to Samuel Rhoads, whose early patents for...

Vasowatch’s proprietary labor and delivery technology was born and raised in Philadelphia: created at the University of Pennsylvania and incubated by the Penn Center of Innovation Ventures. One of the company’s founders is a Labor and Delivery nurse with close to thirty years of obstetrics nursing experience. Another co-founder is...

Philadelphia has long been a city of innovation. For the last 25 years, Integral Molecular has helped write that story, advancing better, safer antibody drugs and developing tools that accelerate vaccine discovery. Founded and grown in Philadelphia, Integral Molecular develops and applies innovative technologies to study and target membrane proteins...

Founded in 1976, in celebration of America’s Bicentennial, the Afro-American Historical and Cultural Museum, now the African American Museum in Philadelphia (AAMP), became the first museum funded and built by a municipality to preserve, collect, and interpret the history of its African American citizens. The museum opened its doors to...

PIDC is Philadelphia’s public-private economic development corporation founded by the City of Philadelphia and the Chamber of Commerce for Greater Philadelphia in 1958. Its mission is to create quality jobs and grow a global economy through economic development that ultimately achieves a high quality of life for all who live...

CARBON REFORM TURNS EVERYDAY HVAC INFRASTRUCTURE INTO A PLATFORM FOR ENERGY SAVINGS, CLEAN AIR, AND CARBON REMOVAL Most climate solutions feel far removed from everyday life. Direct air capture, industrial-scale carbon removal, next-generation infrastructure – these approaches matter, but they often feel inaccessible or years away from practical use. Carbon...

For more than 50 years, Children’s Crisis Treatment Center (CCTC) has played a critical role in supporting the mental and behavioral health of children and families across the Philadelphia region. Each year, the organization serves more than 3,500 children and caregivers, providing care that is grounded in both clinical expertise...

A LEARNING PLATFORM DESIGNED FOR REAL ADULTS NAVIGATING REAL LIVE. What does Adult You do? Adult You harnesses industry-leading gamified learning to empower adults with essential life skills, making personal growth as engaging as the best games and social platforms. We’re here to help adults thrive in their everyday lives....

Economic impact has a standard playbook: count jobs, measure spending, calculate activity, and produce a number. Oftentimes this approach defines how cities, institutions, and developers tell their economic story, but it can leave out the most important part—the context of the place and the tangible day-to-day impacts on the community....

Our durable, low-energy Split Flap, Picture Flap, and Chroma Flap displays are designed to last for decades, and are crafted for spaces where permanence and presence matter. Founded in 2013, Oat Foundry was started by a group of engineering students from Drexel University. Fueled by the ambition to “build cool...

Philadelphia’s real estate landscape is rapidly evolving. Shifts in work patterns, the growth of life sciences and advanced manufacturing, and increased expectations for sustainability, affordability, and community impact are reshaping demand. In this environment, successful development requires more than opportunistic execution—it demands patient capital, long-term planning, and the ability to...

How PECO Is Building a More Reliable, Affordable, and Innovative Energy Future for Greater Philadelphia Powering Innovation for America’s Next Chapter Philadelphia has long been defined by innovation and leadership—from its role as the birthplace of American democracy to its legacy as a center of industrial and technological progress. As...

Adare Pharma Solutions is a global technology-driven contract development and manufacturing organization (CDMO) providing end-to-end integrated services, from product development through commercial manufacturing and packaging, with small molecule expertise focusing on oral dosage forms for the pharmaceutical industry. Adare’s specialized technology platforms provide taste masking, customized release, multiparticulate systems, and...

Philadelphia served as the catalyst city for dreaming about a new form of government during the American Revolution. The status quo was monarchs. People were being taxed to fund foreign wars, not public services. Philadelphians believed, and built, a better government for the people. 250 years later, FSH Technologies and...